Biological evaluation and phytochemical investigation of the efficacy of the ethanol extract of the roots of Aristolochia albida, locally used for the treatment of diarrhea and in the form of decoction for the treatment of malaria fever in kaltungo LGA of Gombe State and Gwoza LGA of Borno State, both in North Eastern Nigeria. The pyhtochemical screening confirms the presence of bioactive secondary metabolites: Terpenoids, tannins, glycosides, resins, phlobatannins, alkaloids, flavonoids and saponnins, while sterols and phenols were absent. Antimicrobial activity of the extracts indicated significant activity on Escherichia coli, Shigella dysentry, Pseudomonas aeruginosa, Staphylococcus aureus and inactivity in Salmonella typhii and Streptococcus pyogene. This correlates ethnomedical claims and thus provides for the first time, the pharmacological basis for the folkloric usage of these roots as diarrhea and malaria cure in both States.